Keynote Speaker
Prof. Aziz AMINE

Prof. Aziz AMINE

Faculty of Sciences and Techniques, Hassan II University of Casablanca, Morocco
Speech Title: Recent Advances in Biosensors Based on Enzymatic Inhibition

Abstract: A biosensor is an analytical tool that integrates a bioreceptor with a physical transducer to detect specific components in a sample. Biosensors utilizing enzyme inhibition offer a cost-effective means for swiftly screening inhibitors such as pesticides, aflatoxins, cyanide, sulfide, methylmercury, cadmium ions, nerve agents, antibiotics, and various other drugs and contaminants. These biosensors serve as complementary methods to conventional techniques primarily relying on high-performance liquid chromatography, gas chromatography, atomic absorption or emission spectrometry, and mass spectrometry.
The upcoming conference aims to elucidate recent advancements in biosensing methodologies based on enzyme inhibition, with a focus on several key areas:
• A novel theoretical approach for diagnosing the type of inhibition and assessing kinetic parameters. Introduction of a novel graphical method plotting fifty percent inhibition (I50) against time at various substrate concentrations.
• Introduction of a novel graphical method plotting fifty percent inhibition (I50) against time at various substrate concentrations
• Incorporation of nanomaterials and their impact on signal amplification and sensitivity enhancement.
• Development of a simple method for enzyme immobilization and the creation of a paper sensor coupled with a smartphone for detection purposes.
The conference will also highlight the real-world applications of biosensors based on reversible and irreversible enzyme inhibition, showcasing their analytical performance in terms of analysis time, detection limit, and matrix effect. Additionally, the advantages and limitations of "nanozymes," nanoparticles possessing intrinsic enzyme-like activity, will be a focal point of discussion at the conference.
Keywords: enzyme; biosensors; inhibition; bioanalysis

Biography: Aziz Amine is currently a Full Professor at Hassan II University of Casablanca in Morocco. He obtained his Ph.D. degree from the Free University of Brussels in 1993. For the past 30 years, Professor Amine's research has centered on sensors and biosensors, specifically in Analytical Chemistry and bioelectrochemistry. He has authored over 200 papers, served as coordinator for various national and international research projects, and holds the position of Editor of Section at the journal Biosensors & Bioelectronics. As of February 2024, his research indicators on Google Scholar include an h-index of 62 and 11,700 citations. He was ranked among the top 2% of scientists worldwide in 2019, 2020, 2021, and 2022.